Funded by the European Union - NextGenerationEU Program
    MUR PNRR    PNRR Italia Domani

The Matrix of Resistance: Unveiling the Mechanisms of Extracellular DNA-Mediated Antimicrobial Protection in Biofilms
(RN3) AH-INF Mid Career Award 2023 (Internal Call):
The Matrix of Resistance: Unveiling the Mechanisms of Extracellular DNA-Mediated Antimicrobial Protection in Biofilms

The Matrix of Resistance: Unveiling the Mechanisms of Extracellular DNA-Mediated Antimicrobial Protection in Biofilms


AH-INF Mid Career Award 2023 (Internal Call) - within Research Node 3

Biofilms, complex microbial communities encased in a self-produced extracellular matrix, represent a significant challenge in various environments, particularly in clinical settings where they cause persistent and chronic infections. Within this matrix, bacterial extracellular DNA (eDNA) has emerged as a fundamental component, playing diverse roles in attachment, aggregation, stabilization, and maturation. Importantly, eDNA serves as a key mediator of antibiotic resistance, shielding bacterial communities and facilitating the horizontal transfer of resistance genes.

The focus of this project is on biofilm streamers - suspended filamentous bacterial biofilms prevalent in flowing systems - where eDNA serves as the backbone of these structures, essential for their formation and stability.

The project will encompass two primary objectives:

This approach will shed light on the mechanisms underpinning antibiotic resistance in biofilms, with significant implications for infection control strategies.



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Institutions involved: HUNIMED


Funds Awarded: EUR 150’000.00


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PROJECT INVESTIGATOR(S):


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AH-INF MCA projects are the result of a partnership between INF-ACT Foundation and The Giovanni Armenise-Harvard Foundation. Both Foundations share the common goal to support a category of basic scientists, i.e. the Mid-Career researchers, who are currently insufficiently supported, with the common objective to set a new trend and inspire other foundations, private and public institutional donors to help with this critical need.


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INF-ACT is a Participated Foundation (Fondazione di Partecipazione)
Codice Fiscale 96084470184 - Partiva IVA 02894510185
Address: Corso Strada Nuova, 65 - 27100 Pavia (Italy)
Contact e-mail: management@inf-act.it - PEC: inf-act@pec.it

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The INF-ACT Foundation is the Hub of the a project funded under the National Recovery and Resilience Plan (NRRP), Mission 4 Component 2 Investment 1.3 - Call for tender No. 341 of 15 March 2022 of Italian Ministry of University and Research funded by the European Union - NextGenerationEU; Project code PE00000007, Concession Decree No. 1554 of 11 October 2022 adopted by the Italian Ministry of University and Research, Project title "The Matrix of Resistance: Unveiling the Mechanisms of Extracellular DNA-Mediated Antimicrobial Protection in Biofilms".


Funded by the European Union - NextGenerationEU Program
    MUR PNRR    PNRR Italia Domani




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