Giuseppe Manco graduated with honors in Biological Sciences from the University of Naples Federico II in 1987. In 1995, he was a Visiting Scientist at the NIH, Bethesda, USA. He joined the Italian National Research Council (CNR) in 1994 as a Research Scientist at the Institute of Protein Biochemistry (IBP), served as Senior Researcher from 2001 to 2019, and has been Research Director at the Institute of Biochemistry and Cell Biology (IBBC-CNR) since 2020. He obtained the Italian National Scientific Qualification for Full Professor in Biochemistry (2014) and in Molecular Biology (2018). Throughout his career, he has coordinated and led several nationally and internationally funded research projects. He is the author of more than 120 scientific publications, holder of patents, and founder of the innovative startup Detoxizymes S.r.l. In 2026, his Google Scholar H-index is 37. His research has focused on the structure-function relationships of enzymes with biotechnological relevance. Among his major contributions is the discovery of a new family of thermostable lactonases, for which he solved the first three-dimensional structure and promoted their structural, functional, and biotechnological characterization. His current research is devoted to the function and regulation of the human lactonase PON2 and its role in physiological and pathological processes.
